Analysis of human fluid proteomic studies related to aging and frailty

The data collection is organized into four complementary databases. The first database includes several distinct datasets from age- and frailty-related proteomic studies:• Proteins identified in age-related studies with p-values prior to Benjamini-Hochberg correction• Proteins identified in frailty-related studies with p-values prior to Benjamini-Hochberg correction• Proteins identified in age-related studies with expression pattern after Benjamini-Hochberg correction• Proteins identified in frailty-related studies with expression pattern after Benjamini-Hochberg correction• Proteins commonly identified in age-related studies.• Proteins commonly identified in frailty-related studies.• Proteins shared between the two previous datasets, present in at least two age-related studies and two frailty-related studies. The second database includes results from biological pathways in two software: STRING and Reactome. These datasets were generated from the proteins extracted in the first database. The datasets include:• STRING biological pathway results for proteins commonly identified in frailty-related studies.• STRING biological pathway results for proteins commonly identified in age-related studies.• STRING biological pathway results for proteins shared between the two previous groups (≥2 age-related and ≥2 frailty-related studies).• Reactome pathway analysis results for proteins commonly identified in frailty-related studies.• Reactome pathway analysis results for proteins commonly identified in age-related studies.• Reactome pathway analysis results for proteins shared between the two previous groups.• Summary of biological pathways results for proteins shared between the two previous groups.• Meta-regression statistical results of STRING biological pathways across age- and frailty-related studies. The third database compiles proteins citations from the scientific literature and biological pathways of the two main frailty scales. The datasets include: Common proteins in age studies Common proteins in frailty studies Biological pathways of Fried score-associated proteins indentified in at least two studies Biological pathaways of Frailty Index-associated proteins identified in at least two studies The fourth database contains the graphical outputs of the meta-regression analysis. The datasets include: 23 forest plots of studies assessing the association between age or frailty and selected biological process 23 funnel plots assessing publication bias in studies investigating the association between age or frailty and selected biological process