Characterization data of commercial tracers for magnetic particle imaging

This dataset contains characterization data for various commercially available tracers for magnetic particle imaging (MPI). Currently this includes Synomag-D with plain, NH2, and PEG modified coatings, Perimag, Vivotrax, and Vivotrax Plus. The dataset includes data on particle physical and magnetic properties, like dynamic light scattering, magnetization versus applied field, and zero-field-cooled/field-cooled magnetization measurements, as well as direct evaluations of tracer MPI performance as measured through RELAX and 2D scans on a Magnetic Insight MOMENTUM imager. A table of relevant particle properties is additionally provided as a summary of the processed measurement data for researchers to evaluate directly. All measurements used to generate these values are also provided to allow the evaluation of other analysis methods. Further, this dataset allows for the comparison of several commonly used commercial MPI tracers using a single instrument and consistent procedures. This is us..., Dynamic Light Scattering
Hydrodynamic diameter measurements of particles diluted in deionized water were obtained at room temperature using a Brookhaven ZetaPALS as an intensity-weighted lognormal distribution.
Iron Concentration Assay
Iron concentration of all tracers was determined by a colorimetric assay using 1,10-phenanthroline. 10 µL of commercial tracers were digested in 1 mL of 70% nitric acid overnight at 101 °C. The following day, 10 µL of the digested sample was placed in a quartz 96-well plate and dried on a hot plate at 115 °C. The plate was transferred into an OT2 liquid handling robot (Opentrons, Long Island City, NY, US) where 46 µL of DI water followed by 30 µL of hydroxylamine hydrochloride (8.06 M) was added and allowed to react for 1 hour. 49 µL of sodium acetate (1.22 M) and 75 µL of 1,10-phenanthroline monohydrate (13 mM) were then added to complex with the Fe2+. Absorbance measurements at 508 nm were collected in a SpectraMax M5 microplate reader (Molecular Device..., , # Dataset title: Characterization data of commercial tracers for magnetic particle imaging

### Principal Investigator Contact Information

Carlos M. Rinaldi-Ramos

Institution: University of Florida

Email: [[e-mail]](mailto:[e-mail])

### Alternate Contact Information

Name: Eric Daniel Imhoff

Institution: University of Florida

Email: [[e-mail]](mailto:[e-mail])

## Dates of Data Collection

Data was collected throughout 2024.

## Funding

This work was supported by the National Institute for Biomedical Imaging and Bioengineering under award number R01EB031224.

## Data Sources

All data were derived from measurements performed by the authors using the instrumentation described in the methods.

## Recommended Citation for the Data Set

Imhoff, Eric D.; Melnyk, Andrii; Rinaldi-Ramos, Carlos M. (2025). Characterization data of commercial tracers for magnetic particle imaging [Dataset]. Dryad. doi: 10.5061/dryad.j3tx95xs0

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