HepG2 and K562 cCRE syntenic ages

### DESCRIPTION ### HepG2 and K562 ENCODE 3 cCRE pELS, dELS, pELS + CTCF, dELS +CTCF. ### METHOD ### To assign sequence ages enhancer cCRE .bed coordinates were intersected with hg38 100-way multiZ alignment syntenic blocks from UCSC genome browser. ### Column names ### [#chr start_syn end_syn enh_id #chr_enh start_enh end_enh segment_number simple_0_complex_1 core_0_derived_1 mrca_age] ### explanation of column names ### [#chr start_syn end_syn]: syntenic block .bed coordinates in hg38 [ enh_id #chr_enh start_enh end_enh]: cCRE .bed coordinates in hg38 [segment_number]: We count the number of syntenic block segments overlapping a single enhancer. [simple_0_complex_1]: Some syntenic blocks overlap multiple syntenic blocks, which we term "complex". Others overlap a single syntenic block, which we term "simple". Complex elements are annotated with 1 and simple elements are annotated with 0. [core_0_derived_1]: In complex enhancer sequences (i.e. enhancer sequences with multiple sequence ages). We refer to the oldest sequence in an enhancer is the "core" (annotated as 1) and the younger sequence age(s) as "derived" (annotated as 0). [mrca_age]: For each syntenic segment, we annotate the most recent common ancestor (MRCA) age. This corresponds to the estimated branch length between humans and the related MRCA. Taxon and summarized taxon ("Taxon2") for each MRCA age is annotated in the hg38_syn_taxon.bed file.