RNA Nanotherapeutics with Fibrosis Overexpression and Retention (FORT) for MASH Treatment

Name: RNA Nanotherapeutics with Fibrosis Overexpression and Retention (FORT) for MASH Treatment
Creator: Ke, Yubin; xian, xunde; Yin, Jie; Lai, Pingping; Zhou, Yilong; Liu, Wei; Xue, Yizhe; Delcassian, Derfogail; Liu, Yuxiu; Miao, Lei; Shan, Xinzhu; Lin, Jiaqi; Jiang, Hanqiu; Li, Bu Yao; Zhang, Zihan; Ma, Bin; Lu, Xueguang; Wang, Qian; Zhao, zhiqiang; Luo, Cong; Li, Wenzhe; Wei, Chenlong; Qin, PengXia; Ge, Yifan; Shu, Li
Published: 2024-08-28 00:00:00
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Figshare2024-08-28 更新2026-04-08 收录

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https://springernature.figshare.com/articles/dataset/RNA_Nanotherapeutics_with_Fibrosis_Overexpression_and_Retention_FORT_for_MASH_Treatment/26212364/1

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资源简介：

we present a new approach to treat fibrotic diseases, termed “Fibrosis overexpression and retention (FORT)”. In this strategy, we design 1) retinoid-derivative lipid nanoparticle (LNP) to enable enhanced mRNA overexpression in fibrotic regions, and 2) mRNA modifications which facilitate anchoring of therapeutic proteins in ECM.

提供机构：

Ke, Yubin; xian, xunde; Yin, Jie; Lai, Pingping; Zhou, Yilong; Liu, Wei; Xue, Yizhe; Delcassian, Derfogail; Liu, Yuxiu; Miao, Lei; Shan, Xinzhu; Lin, Jiaqi; Jiang, Hanqiu; Li, Bu Yao; Zhang, Zihan; Ma, Bin; Lu, Xueguang; Wang, Qian; Zhao, zhiqiang; Luo, Cong; Li, Wenzhe; Wei, Chenlong; Qin, PengXia; Ge, Yifan; Shu, Li

创建时间：

2024-08-28