Identification of genes associated with Periodontal pathogens induced endothelial dysfunction using RNA-seq data

Periodontal pathogens (Porphyromonas gingivalis, Fusobacterium nucleatum) are known as one of several important bacterial pathogens associated with sporadic Alzheimer's disease (AD). It is suggested that the entry of Periodontal pathogens into the brain is due to the disruption of the tight junctions of endothelial cells by Periodontal pathogens. However, genomic alterations that occur as a result of Periodontal pathogens infection in endothelial cells are not well understood. Our goal was to identify genes associated with Periodontal pathogens infection-induced endothelial dysfunction by integrating gene expression data. Nine samples, 3 controls, 3 F. nucleatum infected, 3 P. gingivalis infected.