HOXA13

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]

在脊椎动物中，编码称为同源盒基因类的转录因子的基因位于分别命名为A、B、C和D的染色体上的簇中。这些蛋白质的表达在胚胎发育过程中具有空间和时间上的调控。该基因位于第7染色体的A簇中，编码一种DNA结合的转录因子，可能调控基因表达、形态发生和分化。编码蛋白中聚丙氨酸序列的扩张可导致手-足-子宫综合征，亦称手-足-生殖器综合征。[提供者：RefSeq，2008年7月]