Top ten 8-mers derived from the set of 6000 randomly generated 500 bp sequences, each having the 8-mer insert ‘ATGCCGTA’.

Three different sets of top ten 8-mers are shown, with the artificially inserted 8-mer marked with an asterisk (*). The first set of top ten 8-mers was obtained after applying the previously published C0/C1 method (a), whereas the other two sets were calculated using our avg (k-1) mer method and ranking the resulting 8-mers based on either their fold enrichment scores (b) or, their Z-scores (c).