Pathway-based tumor mutational burden profile predicts response to immunotherapy and survival in cancer

The core code and data application are listed in our R-based "PathwayTMB" package (https://CRAN.R-project.org/package=pathwayTMB). The package can also be downloaded as follows. In our study, the patient cohorts treated with ICIs inhibitors used in the study are available at www.cbioportal.org. The TCGA-SKCM cohort were downloaded from the GDC TCGA data portal (available at https://portal.gdc.cancer.gov/).