Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by inorganic phosphate

Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by inorganic phosphate Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C. Deposit date: 2022-02-16 Release date: 2022-04-27 Last modified: 2026-03-04 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids. Proc.Natl.Acad.Sci.USA, 119, 2022无机磷酸诱导形成E2P构象的钠钾ATP酶（Na+,K+-ATPase）的冷冻电镜（Cryo-EM）结构 样品描述：1,2-二油酰基-sn-甘油-3-磷酸胆碱、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→3)-[α-D-吡喃甘露糖-(1→6)]β-D-吡喃甘露糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖…… 作者：Kanai, R、Cornelius, F、Vilsen, B、Toyoshima, C 提交日期：2022-02-16 发布日期：2022-04-27 最后修改日期：2026-03-04 实验方法：电子显微镜（分辨率3.8 Å） 引用文献：含与不含强心甾类化合物的两种E2P构象钠钾ATP酶的冷冻电镜研究。《美国国家科学院院刊》，119卷，2022年