Norman et al. 2019 Perturb-seq

Preprocessed CRISPRa Perturb-seq data from Norman et al., 2019 (https://www.science.org/doi/10.1126/science.aax4438) as used in as used in "Modeling variable guide efficiency in pooled CRISPR screens with ContrastiveVI+" (Weinberger et al., 2024).

本数据集为经预处理的CRISPR激活（CRISPR activation, CRISPRa）扰动测序（Perturb-seq）数据，源自Norman等2019年的研究（https://www.science.org/doi/10.1126/science.aax4438），且被用于Weinberger等2024年发表的《基于ContrastiveVI+的混合CRISPR筛选向导RNA效率变异性建模》一文，其原文标题为"Modeling variable guide efficiency in pooled CRISPR screens with ContrastiveVI+"。

搜集汇总

背景与挑战

背景概述

该数据集为Norman et al. 2019 Perturb-seq的预处理CRISPRa Perturb-seq数据，文件大小为425.01 MB，采用CC BY 4.0许可证发布。数据用于单细胞RNA转录组学研究，与Weinberger et al., 2024的研究相关。