Endocrine measurements.

Plasma corticosterone and leptin levels (mean ± SEM, ng/ml), in young adolescent (pnd 50) or adult animals (sacrificed around pnd 90). Animals were exposed to increasing doses of THC (2.5, 5 and 10 mg/kg) or vehicle from pnd 28 to 45, and to MDMA (10 mg/kg) or saline twice daily every 5 days from pnd 30 to 45 (see text for details). In parenthesis, the number of animals per experimental group. ANOVA (P<0.05), asignificant overall effect of sex; esignificant overall effect of THC within the same sex group; gsignificant MDMA effect within the same sex group.