Asymmetric Dearomatization of Naphthols via a Rh-Catalyzed C(sp2)–H Functionalization/Annulation Reaction
收藏acs.figshare.com2023-06-01 更新2025-01-21 收录
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https://acs.figshare.com/articles/dataset/Asymmetric_Dearomatization_of_Naphthols_via_a_Rh_Catalyzed_C_sp_sup_2_sup_H_Functionalization_Annulation_Reaction/2174257/1
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资源简介：
A Rh-catalyzed enantioselective dearomatization
of 1-aryl-2-naphthols with internal alkynes via C–H functionalization
reaction was achieved. In the presence of a chiral Cp/Rh catalyst
and combined oxidants of Cu(OAc)2 and air (oxygen), various
highly enantioenriched spirocyclic enones bearing an all-carbon quaternary
stereogenic center could be synthesized in 33–98% yields with
up to 97:3 er.
通过 Rh 催化下的手性催化脱芳构化反应，实现了1-芳基-2-萘酚与内部炔烃的 C-H 功能化反应。在含有手性 Cp/Rh 催化剂及 Cu(OAc)2 和空气（氧气）混合氧化剂的条件下，可合成多种高度对映富集的螺环烯酮，这些化合物携带全碳的四价立体中心，其产率在 33-98% 之间，对映选择性高达 97:3。
提供机构：
ACS Publications
