Co-crystal structure of Chaetomium glucosidase with compound 9

Co-crystal structure of Chaetomium glucosidase with compound 9 Descriptor: (2R,3R,4R,5S)-2-(hydroxymethyl)-1-(6-{2-nitro-4-[(1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl]anilino}hexyl)piperidine-3,4,5-triol, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Karade, S.S, Mariuzza, R.A. Deposit date: 2022-08-22 Release date: 2023-02-22 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity. J.Med.Chem., 66, 2023毛壳菌葡萄糖苷酶与化合物9的共晶结构 描述：(2R,3R,4R,5S)-2-(羟甲基)-1-(6-{2-硝基-4-[(1R,5S)-3-氧杂-8-氮杂双环[3.2.1]辛烷-8-基]苯胺基}己基)哌啶-3,4,5-三醇、2-[双(2-羟乙基)氨基]-2-羟甲基-1,3-丙二醇、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖…… 作者：Karade, S.S.、Mariuzza, R.A. 提交日期：2022-08-22 发布日期：2023-02-22 最后修改日期：2024-10-30 实验方法：X射线衍射（分辨率2.33 Å） 引用文献：《基于结构设计开发具有抗SARS-CoV-2活性的内质网α-葡萄糖苷酶I强效亚氨基糖抑制剂》，J.Med.Chem., 66, 2023