Structure of MBP-Mcl-1 in complex with MIK665
收藏Protein Data Bank Japan2026-03-04 更新2026-04-25 收录
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Structure of MBP-Mcl-1 in complex with MIK665 Descriptor: (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Judge, R.A, Judd, A.S, Souers, A.J. Deposit date: 2022-09-22 Release date: 2023-11-08 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond), 3, 2023
创建时间：
2022-09-22
