Gene families of putative 2R-ohnologs in the signaling and regulatory networks of ROBO4.

Paralogs were inferred from TreeFam v9 from trees corresponding to family IDs given (www.treefam.org/). In each case, the most recent duplication event was placed at the base of vertebrates by phylogenetic timing. The paralogs listed are descendants of such vertebrate duplication nodes. The ancestral bilaterian gene was inferred on the basis of the fly or worm ortholog. Paralogs directly in the network are highlighted in bold font. Note that many gene members of these gene families are preferentially expressed in ECs, for example: KDR, FLT1, TIE1, TIE2, ROBO4, GATA2.