Triflic Anhydride Promoted Decarboxylative Functionalization of α-Amino Acids

Decarboxylation of naturally abundant amino acids along with subsequent inter- or intramolecular reaction cascade offers rapid synthesis of a variety of complex and high-value amine derivatives. Previous strategies show a high dependency on transition metals, tedious operations, or harsh conditions. Herein, we reported a novel reaction cascade of α-amino acids decarboxylation and nucleophilic functionalization characterized by transition-metal-free, convenient operation, environmentally benign, and mild conditions.