Expression of Jag1 during nephron development

Jag1 is initially expressed in the distal region of renal vesicles then Hnf1b, possibly acting via Dll1 and Notch signaling, maintains Jag1 expression in the distal region of comma-shaped bodies and in the proximal region of S-shaped bodies (Heliot et al. 2013).

Jag1最初在肾小囊的远端区域表达，随后Hnf1b（可能通过Dll1和Notch信号传导途径作用）维持Jag1在逗号状体远端区域和S状体近端区域的表达（Heliot等，2013年）。