Structure of liver pyruvate kinase in complex with allosteric modulator 17

Structure of liver pyruvate kinase in complex with allosteric modulator 17 Descriptor: (10aP)-6-{[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]methyl}-2,3,8,9-tetrahydroxy-5lambda~6~-dibenzo[c,e][1,2]thiazine-5,5(6H)-dione, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ... Authors: Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M. Deposit date: 2022-12-18 Release date: 2023-04-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.182 Å) Cite: Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators. Eur.J.Med.Chem., 250, 2023与变构调节剂17结合的肝脏丙酮酸激酶（liver pyruvate kinase）结构 描述符：(10aP)-6-{[4-(3,4-二羟基苯-1-磺酰基)苯基]甲基}-2,3,8,9-四羟基-5λ⁶-二苯并[c,e][1,2]噻嗪-5,5(6H)-二酮、1,6-二-O-磷酸-β-D-呋喃果糖、镁离子（MAGNESIUM ION）等 作者：Lulla, A、Nilsson, O、Brear, P、Nain-Perez, A、Grotli, M、Hyvonen, M 存入日期：2022-12-18 发布日期：2023-04-12 最后修改日期：2024-05-22 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.182埃 引用文献：通过一类新型变构调节剂调控肝脏丙酮酸激酶活性，《欧洲药物化学杂志（Eur. J. Med. Chem.）》，250卷，2023年