Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation

Data for "Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation"

Data directories

bulk-1week

Contains processed bulk TCR sequencing data from cohort 1.

longitudinal

Contains processed bulk TCR sequencing data from cohort 2.Note that this is the same dataset as reported in the following reference (it is included again in this repository for completeness):B. Ogunjimi, J. Van den Bergh, P. Meysman, S. Heynderickx, K. Bergs, H. Jansens, E. Leuridan, A. Vorsters, H. Goossens, K. Laukens, N. Cools, V. Van Tendeloo, N. Hens, P. Van Damme, E. Smits, P. Beutels, Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox. Sci Rep 7, 1077 (2017).

single-cell

Contains processed single cell data from cohort 1.

stim

Contains TCR data from stimulation experiments.

Script directories

src

Contains various scripts used to generate the results and figures in the manuscript.

Result directories

results

Contains the inbetween files for many of the analyses.Contains the Seurat object for the single cell analysis reported in the paper.Also used as output directory for the scripts listed in src.

tcrex_results

Full results from using the aforementioned data sets with the TCRex tool:https://tcrex.biodatamining.be/