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Isocitrate Lyase-1 from Mycobacterium tuberculosis covalently modified by 5-descarboxy-5-nitro-D-isocitric acid

NIAID Data Ecosystem2026-05-02 收录

抗结核药物靶点

共价修饰

数据链接：

https://www.rcsb.org/structure/7RB1 数据链接链接失效反馈

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资源简介：

Isocitrate Lyase-1 from Mycobacterium tuberculosis covalently modified by 5-descarboxy-5-nitro-D-isocitric acid

应用场景：

创建时间：

2024-11-13

共价修饰

质谱分析

*indicates conformation of protein adduct by MS/MS. Type of adduct refers to either (1) MA = Michael addition or (2) SB = Schiff base. Modifications were identified on Cys69 of both apo and holo r

NIAID Data Ecosystem70

KatG inactivation generates vulnerabilities in isoniazid resistant strains of Mycobacterium tuberculosis

结核病耐药性

抗结核药物靶点

Drug-resistant strains of Mycobacterium tuberculosis are a major global health problem. Resistance to the front-line anti-tubercular isoniazid is often associated with mutations in the katG encoded bi

NIAID Data Ecosystem30

The 1.6 A Crystal Structure of MshC: The Rate Limiting Enzyme in the Mycothiol Biosynthetic Pathway

晶体结构解析

抗结核药物靶点

The 1.6 A Crystal Structure of MshC: The Rate Limiting Enzyme in the Mycothiol Biosynthetic Pathway

NIAID Data Ecosystem10

Structure of Mycobacterium Tuberculosis Transcriptional Regulatory Repressor Protein (EthR) in complex with fragment 7G9.

蛋白质复合物结构解析

抗结核药物靶点

Structure of Mycobacterium Tuberculosis Transcriptional Regulatory Repressor Protein (EthR) in complex with fragment 7G9.

NIAID Data Ecosystem50

The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site

蛋白质晶体学

抗结核药物靶点

The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site Descriptor: Alanine racemase, PYRIDOXAL-5'-PHOSPHATE Authors: LeMague

Protein Data Bank Japan2025-03-26 更新20

Isocitrate Lyase-1 from Mycobacterium tuberculosis covalently modified by 5-descarboxy-5-nitro-D-isocitric acid

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