Crystal structure of active KRAS-G12C (GMPPNP-bound) in complex with BBO-8520

Crystal structure of active KRAS-G12C (GMPPNP-bound) in complex with BBO-8520 Descriptor: BBO-8520 (bound form), GTPase KRas, MAGNESIUM ION, ... Authors: Chan, A.H, Ashraf, M, Dharmaiah, S, Simanshu, D.K. Deposit date: 2023-11-27 Release date: 2024-12-18 Last modified: 2025-03-12 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C. Cancer Discov, 15, 2025与BBO-8520结合的活性KRAS-G12C（结合GMPPNP）晶体结构 数据集描述：BBO-8520（结合态）、GTP酶KRas、镁离子…… 作者：Chan, A.H.、Ashraf, M.、Dharmaiah, S.、Simanshu, D.K. 提交日期：2023-11-27 发布日期：2024-12-18 最后更新日期：2025-03-12 实验方法：X射线衍射（分辨率2.1 Å） 引用文献：《BBO-8520的发现：首款直接共价双重靶向GTP结合态（ON）与GDP结合态（OFF）KRASG12C的抑制剂》，《癌症发现（Cancer Discov）》，2025年，第15卷