FBXO45, a new guardian of the genome

Conditional knockout of Fbxo45 in alveolar epithelial type II cells (AT2) in mice (cKO) resulted in spontaneous lung adenocarcinoma. To investigate why deletion of Fbxo45 in AT2 leads to lung adenocarcinoma. We isolated primary AT2 cells from 6-month-old WT, cKO mice for high-throughput RNA-sequencing analysis. (WT=2, cKO=2) Overall design: Comparative gene expression profiling analysis of RNA-seq data for WT-AT2 cells and KO-AT2 cells.