Factor VIIa in complex with the inhibitor 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-7-yl]cyclohexane-1-carboxylic acid

Factor VIIa in complex with the inhibitor 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-7-yl]cyclohexane-1-carboxylic acid Descriptor: 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-7-yl]cyclohexane-1-carboxylic acid, CALCIUM ION, Coagulation factor VII (Heavy Chain), ... Authors: Wei, A. Deposit date: 2016-08-02 Release date: 2016-09-28 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors. Bioorg.Med.Chem.Lett., 26, 2016

凝血因子VIIa（Factor VIIa）与抑制剂1-[(2R,15R)-2-[(1-氨基-4-氟异喹啉-6-基)氨基]-4,15,17-三甲基-3,12-二氧代-13-氧杂-4,11-二氮杂三环[14.2.2.1~6,10~]二十一碳-1(18),6(21),7,9,16,19-六烯-7-基]环己烷-1-羧酸形成的复合物。描述符：1-[(2R,15R)-2-[(1-氨基-4-氟异喹啉-6-基)氨基]-4,15,17-三甲基-3,12-二氧代-13-氧杂-4,11-二氮杂三环[14.2.2.1~6,10~]二十一碳-1(18),6(21),7,9,16,19-六烯-7-基]环己烷-1-羧酸、钙离子（CALCIUM ION）、凝血因子VII（重链）(Coagulation factor VII (Heavy Chain))……作者：Wei, A.。存档日期：2016-08-02；发布日期：2016-09-28；最后修改日期：2024-11-13。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.79埃（Å）。引用文献：《强效大环组织因子-凝血因子VIIa抑制剂的合成及P1'位构效关系探索》，发表于《Bioorg.Med.Chem.Lett.》2016年第26卷。