Descriptive statistics of metabolites in purine pathway.

* Wilcoxon rank sum test. † Wilcoxon signed ranks test. ‡Each value represents ng/mL. Xant and Gr have some left-censored values, so the listed mean estimates may be too large by up to 3.76 (HC), 0.60 (FENNS-BL), 1.20 (FENNS-4W) for Xant, and 0.94 (HC), 0.79 (FENNS-BL), 1.47 (FENNS-4W) for Gr. § Significance with p<0.0083 in boldface, trends with p<0.0167, after Bonferroni correction. Abbreviations: HC, healthy control subjects; FENNS, first-episode neuroleptic-naïve patients with schizophrenia; BL, baseline; 4w, 4-week treatment with antipsychotic drugs; UA, uric acid; Xan, xanthine; Xant, xanthosine; G, guanine; Gr, guanosine; Hx, hypoxanthine.