Genome-wide expression reveals multiple systemic effects of anticoagulant poisons in bobcats (Lynx rufus). Genome-wide expression reveals multiple systemic effects of anticoagulant poisons in bobcats (Lynx rufus)

We evaluated AR-related effects on genome wide expression patterns in a population of bobcats in southern California. We identify differential expression of genes involved in xenobiotic metabolism, endoplasmic reticulum stress response, epithelial integrity, and both adaptive and innate immune function. Further, we find that differential expression of immune related genes may be attributable to AR-related effects on leukocyte differentiation. Collectively, our results provide an unprecedented understanding of the sublethal effects of AR exposure on a wild carnivore. Overall design: Blood samples from 26 bobcats tested positive for Anticoagulant Rodenticides (Ars) and 26 samples of bobcats not tested positive for ARs.