BRCA2-N-terminus interacting proteins in HEK293T cells

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DNA-RNA杂合体解析

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BRCA2 promotes DNA-RNA hybrid resolution by DDX5 at DNA double-strand breaks to facilitate homologous recombination

创建时间：

2021-01-27

BRCA1 recruitment to damaged DNA sites is dependent on CDK9

DNA损伤响应

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Double strand break lesions, the most toxic type of DNA damage, are repaired primarily through 2 distinct pathways: homology-directed recombination (HR) and non-homologous end-joining (NHEJ). BRCA1 an

DataCite Commons2020-09-02 更新120

Mechanism of homology search expansion during recombinational DNA break repair. Saccharomyces cerevisiae W303

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Hi-C染色质构象分析

Hi-C and ssHi-C paired-end Illumina reads generated as part of the work "Mechanism of homology search expansion during recombinational DNA break repair"

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PRMT5 regulates the homologous recombination DNA repair pathway by controlling the alternative splicing of key epigenetic factors

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RNA剪接调控

We found that PRMT5 deletion or inhibition impairs homologous recombination (HR) DNA repair, leading to DNA damage accumulation, p53 activation, cell cycle arrest and cell death through missplicing of

Alliance of Genome Resources10

The spliceosome-associated protein Nrl1 promotes DNA repair and suppresses R-loop formation in fission yeast

R-loop与基因组不稳定性

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The formation of RNA-DNA hybrids referred as to R-loops can promote genome instability and cancer development. Yet the mechanisms by which R-loops compromise genome instability are poorly understood.

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List of oligonucleotides.

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核酸酶保护试验

Primers 1–5 were used to isolate and modify the cDNA encoding E. histolytica DMC1 and RAD51. H3, OL83-1, and OL90 were 32P-radiolabeled using [32P-γ]-ATP and T4-PNK. 32P-H3 and 32P-OL83-1 were anneale

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BRCA2-N-terminus interacting proteins in HEK293T cells

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