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Inhibition of Insulin-Regulated Aminopeptidase: A Novel Therapeutic Strategy for Stroke

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Monash University Figshare2026-02-11 更新2026-07-07 收录
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This thesis characterises and validates a preclinical model of stroke that closely mimics human stroke. In this preclinical model, novel drug therapies that target the insulin-regulated aminopeptidase (IRAP), an enzyme found in the brain, were tested. This thesis identified that following stroke, targeting IRAP reduces tissue damage in the brain and improves physical mobility.

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2022-11-07
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