SULT1A3,4 dimers sulfate DA to DAOS
收藏reactome.org2025-03-26 收录
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The catecholamine neurotransmitter dopamine (DA) is predominantly (>95%) conjugated with sulfate (dopamine 3-O-sulfate, DAOS) in human blood circulation. Human SULT1A3 and SULT1A4 are the major sulfotransferases that sulfonate DA (as well as other catecholamines and phenols) (Reiter et al. 1983, Johnson et al. 1980, Thomae et al. 2003, Hildebrandt et al. 2004).
儿茶酚胺类神经递质多巴胺(DA)在人体血液循环中主要(>95%)与硫酸盐结合(多巴胺3-O-硫酸盐,DAOS)。人类SULT1A3和SULT1A4是主要的硫酸转移酶,负责将多巴胺(以及其他儿茶酚胺和酚类化合物)进行硫酸化(Reiter等,1983年,Johnson等,1980年,Thomae等,2003年,Hildebrandt等,2004年)。
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