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Small molecule-controlled genome editing using agRNAs

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下载链接:
https://www.ncbi.nlm.nih.gov/sra/SRP106902
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By incorporating ligand-responsive self-cleaving catalytic RNAs (aptazymes) into guide RNAs, we developed a set of aptazyme-embedded guide RNAs that enable small molecule-controlled nuclease-mediated genome editing and small molecule-controlled base editing, as well as small molecule-dependent transcriptional activation in mammalian cells.
创建时间:
2017-05-12
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