Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse

Studies of human perception have shown early cortical signals for primary information encoding, and later signals for higher order processing. An important late signal is the cortical event-related desynchronization (ERD) in the alpha (8-12Hz) and beta (12-30Hz) frequency band, which has been linked to human perceptual awareness. Detailed mechanistic investigation of the ERD would be greatly facilitated by availability of a suitable animal model. We conducted local field potential recordings in the mouse frontal association cortex (FrA), thalamic intralaminar centrolateral nucleus (CL), primary auditory cortex (A1), and primary visual cortex (V1) during two auditory tasks. Fully audible brief 50 ms stimuli with both tasks produced early broadband gamma (30-100Hz) frequency activity at 0-250ms, followed by a late cortical alpha/beta ERD 250 – 750 ms after stimulus onset. The ERD was statistically significant in FrA and A1, but not in V1. Interestingly, a significant ERD was also observed..., , # Data from: Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse

This repository contains the complete, unprocessed dataset underlying the publication:

McGill, S. H., Xin, Q., Yadav, T., Zhao, C. W., Paszkowski, P., Darby, F., Guha, M., Nguyen, T., Jin, D. S., Nir, Y., Liu, J., Sieu, L-A., & Blumenfeld, H. (2025). Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse. PLOS ONE, 20(10), e0334293. [https://doi.org/10.1371/journal.pone.0334293](https://doi.org/10.1371/journal.pone.0334293)

The repository archives all raw behavioral, electrophysiological, histological, and metadata files associated with this study, organized for transparency and reuse in accordance with best-practice guidelines of Dryad and PLOS One.

## 1. Overview

The study investigated neural correlates of auditory processing in mice by recording local field potentials (LFPs) from the frontal association cortex (FrA), ...,