Pharmacological Activation of SIRT1-AMPK by Ginsenoside Rb1: A Novel Therapeutic Strategy for Pressure Injury via Dual Suppression of Ferroptosis and Inflammation

Pressure injuries (PIs) remain a major clinical challenge, and current treatments provide limited efficacy. Ferroptosis-driven oxidative injury and persistent inflammation can severely impair wound healing. Ginsenoside Rb1 (Rb1), a major bioactive component of Panax ginseng, exhibits antioxidant and anti-inflammatory activities; however, its therapeutic potential in PIs through ferroptosis regulation has not been established. This study investigates whether Rb1 accelerates PI wound repair by activating the SIRT1-AMPK signaling pathway to suppress ferroptosis and inflammation, thereby offering a novel pharmacological strategy for PI management.