Structure–Activity Relationship Study of Cyclic Pentapeptide Ligands for Atypical Chemokine Receptor 3 (ACKR3)
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https://figshare.com/articles/dataset/Structure_Activity_Relationship_Study_of_Cyclic_Pentapeptide_Ligands_for_Atypical_Chemokine_Receptor_3_ACKR3_/6137231
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资源简介：
The
atypical chemokine receptor 3 (ACKR3)/CXC chemokine receptor
7 (CXCR7) recognizes stromal cell-derived factor 1 (SDF-1)/CXCL12
and is involved in a number of physiological and pathological processes.
Here, we investigated the SAR of the component amino acids in an ACKR3-selective
ligand, FC313 [cyclo(-d-Tyr-l-Arg-l-MeArg-l-Nal(2)-l-Pro-)], for the development
of highly active ACKR3 ligands. Notably, modification at the l-Pro position with a bulky hydrophobic side chain led to improved
bioactivity toward ACKR3.
创建时间：
2018-04-12
