CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH n1(C)c(nc(c1)c2ccccc2)CCNC(c3cccn4c(nnc34)C(C)C)=O, micromolar IC50=0.024844

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH n1(C)c(nc(c1)c2ccccc2)CCNC(c3cccn4c(nnc34)C(C)C)=O, micromolar IC50=0.024844 Descriptor: (4S)-N-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl]-3-(propan-2-yl)[1,2,4]triazolo[4,3-a]pyridine-8-carboxamide, MAGNESIUM ION, ZINC ION, ... Authors: Joseph, C, Benz, J, Flohr, A, Koerner, M, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published

人类磷酸二酯酶10（phosphodiesterase 10）与配体n1(C)c(nc(c1)c2ccccc2)CCNC(c3cccn4c(nnc34)C(C)C)=O形成复合物的晶体结构，该配体的微摩尔级半数抑制浓度（IC50）为0.024844。描述项：(4S)-N-[2-(1-甲基-4-苯基-1H-咪唑-2-基)乙基]-3-异丙基[1,2,4]三唑并[4,3-a]吡啶-8-甲酰胺、镁离子（MAGNESIUM ION）、锌离子（ZINC ION）等。作者：Joseph C、Benz J、Flohr A、Koerner M、Rudolph M.G.。归档日期：2022-02-01；发布日期：2022-10-12；最后修改日期：2024-10-16。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.39埃（Å）。引用文献：《人源磷酸二酯酶10复合物晶体结构》，待发表。