ZAP affects Zika virus RNA interactome - Table S1-ChIRP-MS data

One of the most recent advances in the analysis of viral RNA–cellular protein interactions is the Comprehensive Identification of RNA-binding Proteins by Mass Spectrometry (ChIRP-MS). Here, we used ChIRP-MS in mock-infected and Zika-infected wild-type cells and cells knockout for the zinc finger CCCH-type antiviral protein 1 (ZAP). We characterized “ZAP-independent” and “ZAP-dependent” cellular protein interactomes associated with flavivirus RNA and found that ZAP affects cellular proteins associated with Zika virus RNA. The ZAP-dependent interactome identified with ChIRP-MS provides potential ZAP co-factors for antiviral activity against Zika virus and possibly other viruses. Identifying the full spectrum of ZAP co-factors and mechanisms of how they act will be critical to understanding the ZAP antiviral system and may contribute to the development of antivirals., , , # ZAP affects Zika virus RNA interactome - Table S1-ChIRP-MS data

[https://doi.org/10.5061/dryad.280gb5mz5](https://doi.org/10.5061/dryad.280gb5mz5)

Supplementary data

## Description of the data and file structure

**Table S1** **- ChIRP-MS data**

Table S1 ChIRP_MS data, **sheet** “**C Extended Zika interactome**” – Proteins with top 15 Spectral Counts are highlighted in red. RNA helicases are highlighted in yellow.

Table S1 ChIRP_MS data, **sheet** “**D Reference Ooi et al., 2019**” – The same proteins in both studies are highlighted in red.

Table S1 ChIRP_MS data, **sheet** “**F ZAP-independent interactome**” – Proteins with top 15 Spectral Counts are highlighted in red.

Table S1 ChIRP_MS data, **sheet** “**H ZAP-dependent interactome**” – Proteins with top 15 Spectral Counts are highlighted in red. RNA helicases are highlighted in yellow.

The empty cells in files are a result of the programs used.