Crystal structure of NRas-G12D in complex with GDP and compound 1

Crystal structure of NRas-G12D in complex with GDP and compound 1 Descriptor: (5P)-3-chloro-4-cyclopropyl-5-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(4s,7as)-tetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)phenol, CITRIC ACID, GTPase NRas, ... Authors: Johnson, T.A, Cross, J.B. Deposit date: 2025-08-28 Release date: 2026-02-25 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure-Guided Development of NRAS G12D Inhibitors Based on a 5‐Azaindole Core. Acs Med.Chem.Lett., 17, 2026