Functional_characterisation_of_CpG_islands_in_mouse_tissues

NIAID Data Ecosystem2026-03-12 收录

CpG岛功能表征

表观遗传调控

数据链接：

https://www.ncbi.nlm.nih.gov/sra/ERP001225 数据链接链接失效反馈

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资源简介：

This project aims to determine the relationship between the physical properties and distribution of CGIs and relate this to DNA methylation, chromatin state and transcriptional competence.

创建时间：

2021-02-04

DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation [RNA-seq]

表观遗传调控

甲基化反应机制

DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing, gene imprinting, and X chromosome inactivation. It has lon

NIAID Data Ecosystem00

An epigenetic switch in vascular phenotype augments anti-tumor immunity [bulkRNA-seq]

肿瘤免疫微环境

表观遗传调控

The abnormal tumor vasculature can present a barrier to the infiltration of anti-tumor immune cells, which impairs immune surveillance and response to immunotherapy. Here, we show that targeting the e

NIAID Data Ecosystem00

Mitochondrial Fission 1 (FIS1) knockdown effect on the H3K27Ac status of leukemia cell line MOLM-13 cells. Mitochondrial Fission 1 (FIS1) knockdown effect on the H3K27Ac status of leukemia cell line MOLM-13 cells

表观遗传调控

肾病与白血病基因功能研究

To examine if loss of FIS1 would alter the H3K27Ac status of leukemic cells, we used shRNA to knock down the expression of FIS1 in leukemic cell line MOLM-13 cells and performed H3K27Ac CHIP-seq to ch

NIAID Data Ecosystem00

Addressing the specific roles of histone modifications in transcriptional repression [RNA-seq]

组蛋白修饰转录抑制

表观遗传调控

Our understanding of epigenetic processes is based on the hypothesis that individual posttranslational modifications of DNA and histones, or combinations thereof, function to direct unique downstream

NIAID Data Ecosystem00

Stage-specific Kdm6b-transcription factor partnerships orchestrate temporal precision during stepwise motor neuron differentiation [RNA-seq]

运动神经元

表观遗传调控

Histone modifiers instruct cellular differentiation, yet how they achieve temporal precision remains enigmatic. Here we demonstrate that the H3K27 demethylase Kdm6b acts as a master epigenetic conduct

NIAID Data Ecosystem00

Functional_characterisation_of_CpG_islands_in_mouse_tissues

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