A panel of hepatocellular carcinoma cell lines recapitulates the molecular subtypes of the human disease: A model for targeted drug development

RNA expression patterns of liver cell lines were compared to those of liver tumors to determine the suitability of cell lines as a model for drug development studies. The cell lines appear to recapitulate liver tumors. Gene expression of 20 individual liver cell lines relative to a liver cell line reference mix containing equal amounts of 19 liver cell lines. The expression data was correllated with expression in liver tumors.