Efficacy of blockers: summary of post hoc analyses* from bitter rankings in the paired-comparison test 1 by TAS2R38 genotype for each of the two blockers when combined with PROP in each of the two groups: children and adults (means ± SEM).

Abbreviations: PROP, propylthiouracil; SEM, standard error of the mean. Putative bitter blockers—NaG, 0.3 M sodium gluconate; MSG, 0.1 M glutamate. Rankings for bitterness range from 1 (least) to 4 (most); see Table S1 for ranking procedure. Different letters indicate rankings that are statistically different from each other within each row. Genotypes (AA, AP, PP) refer to the bitter-sensitive (P) and bitter-insensitive (A) forms of A49P alleles of the TAS2R38 bitter receptor gene.1All Friedman statistical tests of rank tests were significant at p≤0.05.