Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated SRPK1 peptide (K585ac)

Protein Data Bank Japan2024-10-23 更新2026-03-21 收录

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Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated SRPK1 peptide (K585ac) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, VAG(ALY)YS(ALY)EFFY Authors: Filippakopoulos, P, Picaud, S, Newman, J, Sorrell, F, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Structural Genomics Consortium (SGC) Deposit date: 2017-04-08 Release date: 2018-05-16 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol. Cell, 73, 2019

人类BRD4首个溴结构域（bromodomain）与乙酰化SRPK1肽（K585ac）结合的晶体结构描述符：1,2-乙二醇、含溴结构域蛋白4、VAG(ALY)YS(ALY)EFFY 作者：Filippakopoulos P、Picaud S、Newman J、Sorrell F、von Delft F、Arrowsmith C.H、Edwards A.M、Bountra C，结构基因组学联盟（Structural Genomics Consortium, SGC）提交日期：2017-04-08 发布日期：2018-05-16 最后修改日期：2024-10-23 实验方法：X射线衍射（1.2 Å）引用文献：《靶向BET溴结构域的药理学干预引发的相互作用组重编程》，《分子细胞》，第73卷，2019年

创建时间：

2017-04-08