Independently gated multiple substates of an epithelial chloride-channel protein.
收藏PubMed Central1993-06-15 更新2026-05-16 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC46787/
下载链接
链接失效反馈官方服务：
资源简介：
We have purified a protein from Necturus maculosus gallbladder cells that forms chloride channels in an artificial membrane. The same protein apparently can form channels that are highly selective for chloride but can have conductances varying from 9 to about 150 pS. The high-conductance channels are blocked by the monoclonal antibody used to purify the protein, but this antibody has no effect on the 9-pS channels. The observation that gating of the low- and high-conductance states is independent and that the antibody affects only the latter has implications regarding the control of chloride conductance in cell membranes and the different types of channels described in those cells. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1993-06-15
