Pseudomonas-mediated arginine deprivation downregulates RBM39 and inhibits triple-negative breast cancer progression
收藏科学数据银行2025-02-10 更新2026-04-23 收录
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资源简介：
This dataset presents distinct microbial communities and metabolic signatures between tumor and non-tumor tissues. Key findings highlight the role of Pseudomonas spp. in arginine depletion within the tumor microenvironment (TME), leading to RBM39 downregulation, cancer cell apoptosis, and tumor suppression. The dataset includes analyzed microbial composition, metabolic profiles, and functional evaluations of Pseudomonas spp. through cell biology assays and in vivo tumor-bearing mouse models.
提供机构：
Qingxin Xia; Liyun Zhou; Medical Service Office, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital; School of Life Sciences, Northwestern Polytechnical University; Department of Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital; Jiangong Zhang; Yiwei Li
创建时间：
2025-02-05
