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From Propargylamides to Oxazole Derivatives: NIS-Mediated Cyclization and Further Oxidation by Dioxygen

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NIAID Data Ecosystem2026-03-08 收录
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NIS-mediated iodocyclization of N-sulfonyl propargylamides for the synthesis of various oxazolidines and iodoalkylidenedihydrooxazoles via a 5-exo-dig process is developed. The resulting iodoalkylidene­dihydrooxazoles can be further transformed into the corresponding oxazoles in the presence of dioxygen.

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2016-02-17
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