Anti-lubricin monoclonal antibodies created using lubricin-knockout mice immunodetect lubricin in several species and in patients with healthy and diseased joints.

The epitope motif is repeated is present about 20 times in the lubricin protein sequence. The epitope-specific mAb immunoprecipitated lubricin from human synovial fluid, plasma or serum. The mAb did not immunoprecipitate lubricin from synovial fluid of patients with camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), who genetically lack lubricin.