Supplementary material and data for: Use of pumpkin seed (Cucurbita pepo) versus placebo and versus alpha-blockers in the management of benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials

Supplementary material, extracted dataset and analysis code for the article Use of pumpkin seed (Cucurbita pepo) versus placebo and versus alpha-blockers in the management of benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials, accepted for publication in Acta Cirúrgica Brasileira (manuscript ACB-2026-0260). Review protocol: PROSPERO CRD420261445031. Supplementary_Material_ACB-2026-0260.pdf — S1, PRISMA 2020 checklist; S2, full search strategies by database; S3, GRADE summary-of-findings table; S4, reports excluded at full-text assessment; S5, PRISMA 2020 flow diagram (text version); S6, supplementary figure legends; S7, assessment of the reports not retrieved; Supplementary Figures S1–S16 (leave-one-out and Baujat diagnostics for the primary outcomes; forest plots and diagnostics for the secondary outcomes). Data_and_code.zip — data.csv (study-level data extracted from the eight included randomized controlled trials), rob2_judgements.csv (Cochrane RoB 2 judgements), psa_sensitivity.csv, analysis_pumpkin_seed_BPH.R (R script, package meta, reproducing every pooled estimate, prediction interval, subgroup test, leave-one-out and Baujat diagnostic and the PSA sensitivity analyses), analysis_output.txt (console output with sessionInfo) and the figure files (PNG).