Tau interactome

Data from ProteomeXchange, PXD ID: PXD002058. File: 3_OF_SH-SY5Y_hTau40_minus_plus_RNase_interactome_6_7_8_9_0_1_C18_2.mzml. From ProteomeXchange: {{i}} The tau protein is central to the etiology of several neurodegenerative diseases, including Alzheimer-s disease, a subset of frontotemporal dementias, progressive supranuclear palsy and dementia following traumatic brain injury, yet the proteins it interacts with have not been studied using a systematic discovery approach. The study employed mild in vivo crosslinking, isobaric labeling and tandem mass spectrometry to characterize molecular interactions of human tau in a neuroblastoma cell model. {{/i}}