Transcriptional profiling reveals differential changes in the respective expression of oxytocin and CART mRNA levels in the nucleus accumbens and dorsal striatum of compulsive methamphetamine taking rats (nucleus accumbens)

Methamphetamine addiction is mimicked in rats that self-administer the drug and accelerate their intake when given long access to it. Self-administration (SA) models do not include adverse consequences that are necessary to reach a diagnosis of addiction in humans. Here, we studied transcriptional consequences of methamphetamine SA and repeated foot-shocks in rat brain.甲基苯丙胺成瘾行为可通过自身给药（Self-administration）摄取该药物的大鼠进行模拟，且当获得长期自身给药机会时，大鼠的药物摄取速率会显著加快。自身给药（Self-administration，SA）模型无法涵盖人类成瘾诊断所需的不良后果。本研究以大鼠脑组织为研究对象，探究甲基苯丙胺自身给药（SA）联合反复足部电击所产生的转录层面效应。