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Discovery of naturally occurring ESR1 mutations in widely used estrogen receptor positive breast cancer cell lines

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NIAID Data Ecosystem2026-05-17 收录
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We report the first discovery of naturally occurring ESR1Y537C and ESR1Y537S mutations in MCF7 and MCF7 ESR1-positive cell-lines after acquisition of resistance to long-term-estrogen-deprivation (LTED) and subsequent resistance to fulvestrant (ICIR).

创建时间:
2017-12-01
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