Gene and microRNA expression profiles were generated for a melanoma cell line resistant to the BRAF inhibitor PLX4032 and its parental cell line in order to identify altered gene-microRNA regulatory n
In this report, we generated eight matched pairs of vemurafenib sensitive/resistant melanoma lines and subjected these to concurrent RNA-seq and H3K27Ac ChIP-seq analysis. Globally, we identified two
Supplementary files for 'BRAF inhibition and the spectrum of granulomatous reactions: A review', in publication by the Journal of the American Academy of Dermatology.
Focal amplifications (FAs) resulting in copy number gain of targeted genomic regions can mediate targeted therapy resistance. Understanding the structure, plasticity and vulnerability of FAs is critic
