Structure of full-length human lambda-6A light chain JTO in complex with urea stabilizer 20 [1-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-3-(pyridin-3-ylmethyl)urea]
收藏Protein Data Bank Japan2024-10-30 更新2026-03-28 收录
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Structure of full-length human lambda-6A light chain JTO in complex with urea stabilizer 20 [1-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-3-(pyridin-3-ylmethyl)urea] Descriptor: JTO light chain, N-{2-[7-(diethylamino)-4-methyl-2-oxo-2H-1-benzopyran-3-yl]ethyl}-N'-[(pyridin-3-yl)methyl]urea, PHOSPHATE ION Authors: Yan, N.L, Wilson, I.A, Kelly, J.W. Deposit date: 2021-08-13 Release date: 2022-02-16 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site. Bioorg.Med.Chem.Lett., 60, 2022
全长人源λ-6A轻链JTO与尿素类稳定剂20 [1-(2-(7-二乙氨基-4-甲基-2-氧代-2H-色烯-3-基)乙基)-3-(吡啶-3-基甲基)脲] 的复合物结构
描述项：JTO轻链、N-{2-[7-(二乙氨基)-4-甲基-2-氧代-2H-1-苯并吡喃-3-基]乙基}-N'-[(吡啶-3-基)甲基]脲、磷酸根离子
作者：Yan, N.L、Wilson, I.A、Kelly, J.W.
沉积日期：2021-08-13
发布日期：2022-02-16
末次修改日期：2024-10-30
研究方法：X射线衍射（分辨率2.09埃）
引用文献：《包含简单脲接头模块的淀粉样蛋白生成免疫球蛋白轻链动力学稳定剂揭示新型结合亚位点》，Bioorg.Med.Chem.Lett., 60, 2022
创建时间：
2021-08-13
