Correlation between Minimum Inhibitory Concentration (MIC) values and concentrations of rifampicin, clarithromycin, and amoxicillin used in the time-kill kinetics at 1/20xMIC, 1/4xMIC, 1xMIC, 4xMIC, 10xMIC, 20xMIC, and 100xMIC.

Drug concentrations used in the experiments and the corresponding ones are described in parentheses (μg/mL). Clavulanate was used at fixed 5 μg/mL. The synergistic MIC (MICsyn) was defined as the Most Optical Combinatorial Concentration (MOOC), i.e., the lowest possible concentration of every compound that, when assayed together, prevented bacterial growth [3]. aIn the presence of 5 μg/mL of clavulanate MIC, Minimum Inhibitory Concentration; MICsyn, Synergistic Minimum Inhibitory Concentration; MOCC, Most Optimal Combinatorial Concentration; RIF, rifampicin; CLA, clarithromycin; AMX, amoxicillin; NA, not available.
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